During a speech before the second Virginia Convention, Patrick Henry responds to the increasingly oppressive British rule over the American colonies by declaring, "I know not what course others may take, but as for me, give me liberty or give me death!" [T] Following the signing of the American Declaration of Independence on July 4, 1776, Patrick Henry was appointed governor of Virginia by the Continental Congress.

The first major American opposition to British policy came in 1765 after Parliament passed the Stamp Act, a taxation measure to raise revenues for a standing British army in America. Under the banner of "no taxation without representation," colonists convened the Stamp Act Congress in October 1765 to vocalize their opposition to the tax. With its enactment on November 1, 1765, most colonists called for a boycott of British goods and some organized attacks on the customhouses and homes of tax collectors. After months of protest, Parliament voted to repeal the Stamp Act in March 1765.

Most colonists quietly accepted British rule until Parliament's enactment of the Tea Act in 1773, which granted the East India Company a monopoly on the American tea trade. Viewed as another example of taxation without representation, militant Patriots in Massachusetts organized the "Boston Tea Party," which saw British tea valued at some 10,000 pounds dumped into Boston harbor. Parliament, outraged by the Boston Tea Party and other blatant destruction of British property, enacted the Coercive Acts, also known as the Intolerable Acts, in the following year. The Coercive Acts closed Boston to merchant shipping, established formal British military rule in Massachusetts, made British officials immune to criminal prosecution in America, and required colonists to quarter British troops. The colonists subsequently called the first Continental Congress to consider a united American resistance to the British.

With the other colonies watching intently, Massachusetts led the resistance to the British, forming a shadow revolutionary government and establishing militias to resist the increasing British military presence across the colony. In April 1775, Thomas Gage, the British governor of Massachusetts, ordered British troops to march to Concord, Massachusetts, where a Patriot arsenal was known to be located. On April 19, 1775, the British regulars encountered a group of American militiamen at Lexington, and the first volleys of the American Revolutionary War were fired. 

1806 Lewis and Clark depart Fort Clatsop

After passing a wet and tedious winter near the Pacific Coast, Lewis and Clark happily leave behind Fort Clatsop and head east for home.

The Corps of Discovery arrived at the Pacific the previous November, having made a difficult crossing over the rugged Rocky Mountains. Their winter stay on the south side of the Columbia River-dubbed Fort Clatsop in honor of the local Indians-had been plagued by rainy weather, thieving Indians, and a scarcity of fresh meat. No one in the Corps of Discovery regretted leaving Fort Clatsop behind.

In the days before their departure, Captains Lewis and Clark prepared for the final stage of their journey. Lewis recognized the possibility that some disaster might still prevent them from making it back east and he prudently left a list of the names of all the expedition's men with Chief Coboway of the Clatsops. Lewis asked the chief to give the list to the crew of the next trading vessel that arrived so the world would learn that the expedition did reach the Pacific.

The previous few days had been stormy, but on March 22, the rain began to ease. The captains agreed to depart the next day, and they made a parting gift of Fort Clatsop and its furniture to Chief Coboway.

At 1 p.m. on this day in 1806, the Corps of Expedition set off up the Columbia River in canoes. After nearly a year in the wilderness, they had severely depleted the sizeable cache of supplies with which the expedition had begun--they set off on their return trip with only canisters of gunpowder, some tools, a small cache of dried fish and roots, and their rifles. The expedition had expended almost all of its supplies.

Ahead loomed the high, rugged slopes of the Rocky Mountains that had proved so difficult to cross in the other direction the previous year. This time, however, Lewis and Clark had the advantage of knowing the route they would take. Still, they knew the passage would be difficult, and they were anxious to find the Nez Perce Indians, whose help they would need to cross the mountains.

The months to come would witness some of the most dangerous moments of the journey, including Lewis' violent confrontation with Blackfeet Indians near the Marias River of Montana in July. Nonetheless, seven months later to the day, on September 23, 1806, the Corps of Discovery arrived at the docks of St. Louis, where their long journey had begun nearly two and a half years before.

1983 ARTIFICIAL-HEART PATIENT DIES:

On March 23, 1983, Barney Clark dies 112 days after becoming the world's first recipient of a permanent artificial heart. The 61-year-old dentist spent the last four months of his life in a hospital bed at the University of Utah Medical Center in Salt Lake City, attached to a 350-pound console that pumped air in and out of the aluminum-and-plastic implant through a system of hoses.

In the late 19th century, scientists began developing a pump to temporarily supplant heart action. In 1953, an artificial heart-lung machine was employed successfully for the first time during an operation on a human patient. In this procedure, which is still used today, the machine temporarily takes over heart and lung function, allowing doctors to operate extensively on these organs. After a few hours, however, blood becomes damaged by the pumping and oxygenation.

In the late 1960s, hope was given to patients with irreparably damaged hearts when heart-transplant operations began. However, the demand for donor hearts always exceeded availability, and thousands died every year while waiting for healthy hearts to become available.

On April 4, 1969, a historic operation was performed by surgeon Denton Cooley of the Texas Heart Institute on Haskell Karp, a patient whose heart was on the brink of total collapse and to whom no donor heart had become available. Karp was the first person in history to have his diseased heart replaced by an artificial heart. The temporary plastic-and-Dacron heart extended Karp's life for the three days it took doctors to find him a donor heart. However, soon after the human heart was transplanted into his chest, he died from infection. Seven more failed attempts were made, and many doctors lost faith in the possibility of replacing the human heart with a prosthetic substitute.

In the early 1980s, however, a pioneering new scientist resumed efforts to develop a viable artificial heart. Robert K. Jarvik had decided to study medicine and engineering after his father died of heart disease. By 1982, he was conducting animal trials at the University of Utah with his Jarvik-7 artificial heart.

On December 2, 1982, a team led by Dr. William C. DeVries implanted the Jarvik-7 into Barney Clark. Because Jarvik's artificial heart was intended to be permanent, the Clark case drew worldwide attention. Clark spent his last 112 days in the hospital and suffered considerably from complications and the discomfort of having compressed air pumped in and out of his body. He died on March 23, 1983, from various complications. Clark's experience left many feeling that the time of the permanent artificial heart had not yet come.

During the next decade, Jarvik and others concentrated their efforts on developing mechanical pumps to assist a diseased heart rather than replace it. These devices allow many patients to live the months or even years it takes for them to find a donor heart. Battery powered, these implants give heart-disease patients mobility and allow them to live relatively normal lives. Meanwhile, in the 1990s, the Jarvik-7 was used on more than 150 patients whose hearts were too damaged to be aided by the mechanical pump implant. More than half of these patients survived until they got a transplant.

Today, Jarvik and others are working to develop smaller and more efficient mechanical pump implants. A company called ABIOMED has developed a new permanent artificial heart. This "total replacement" device, which is awaiting FDA approval, is powered by an internal battery and does not require air pumps, thus promising unprecedented mobility to recipients.

At the 1994 annual awards dinner given for Forensic Science, AAFS

President Dr Don Harper Mills astounded his audience with the legal complications of a bizarre death. Here is the story.

On March 23, 1994 the medical examiner viewed the body of Ronald Opus and concluded that he died from a shotgun wound to the head. Mr Opus had jumped from the top of a ten-story building intending to commit suicide. He left a note to the effect indicating his despondency. As he fell past the ninth floor his life was interrupted by a shotgun blast passing through a window, which killed him instantly. Neither the shooter nor the deceased was aware that a safety net had been installed just below the eighth floor level to protect some building workers and that Ronald Opus would not have been able to complete his suicide the way he had planned.

"Ordinarily," Dr Mills continued, "A person who sets out to commit suicide and ultimately succeeds, even though the mechanism might not be what he intended, is still defined as committing suicide." That Mr Opus was shot on the way to certain death, but probably would not have been successful because of the safety net, caused the medical examiner to feel that he had a homicide on his hands.

In the room on the ninth floor, where the shotgun blast emanated, was occupied by an elderly man and his wife. They were arguing vigorously and he was threatening her with a shotgun. The man was so upset that when he pulled the trigger he completely missed his wife and the pellets went through the window striking Mr Opus.

When one intends to kill subject "A" but kills subject "B" in the attempt, one is guilty of the murder of subject "B." When confronted with the murder charge the old man and his wife were both adamant and both said that they thought the shotgun was unloaded. The old man said it was a long-standing habit to threaten his wife with the unloaded shotgun. He had no intention to murder her.

Therefore the killing of Mr Opus appeared to be an accident; that is, if the gun had been accidentally loaded.

The continuing investigation turned up a witness who saw the old couple's son loading the shotgun about six weeks prior to the fatal accident. It transpired that the old lady had cut off her son's financial support and the son, knowing the propensity of his father to use the shotgun threateningly, loaded the gun with the expectation that his father would shoot his mother. Since the loader of the gun was aware of this, he was guilty of the murder even though he didn't actually pull the trigger.

The case now becomes one of murder on the part of the son for the death of Ronald Opus. Now comes the exquisite twist. Further investigation revealed that the son was, in fact, Ronald Opus. He had become increasingly despondent over the failure of his attempt to engineer his mother's murder. This led him to jump off the ten story building on March 23rd, only to be killed by a shotgun blast passing through the ninth story window. The son had actually murdered himself so the medical examiner closed the case as a suicide.

(A true story from Associated Press, Reported by Kurt Westervelt)